This issue of Neuroimaging Clinics of North America focuses on Imaging of Multiple Sclerosis: Diagnosis and Management, and is edited by Dr. Àlex Rovira Cañellas. Articles will include: Multiple Sclerosis: Epidemiological, Clinical and Therapeutic Aspects, Brain and Spinal Cord MR Imaging Features in Multiple Sclerosis and Variants, Neuromyelitis Optica Spectrum Disorders, Radiologically Isolated Syndrome, MRI in Monitoring and Predicting Treatment Response in Multiple Sclerosis, Cortical Grey Matter MR Imaging in Multiple Sclerosis, Brain Atrophy in Multiple Sclerosis: Technical Aspects and Clinical Relevance, Iron Mapping in Multiple Sclerosis, Microstructural MR Techniques in Multiple Sclerosis, Molecular and Metabolic Imaging in Multiple Sclerosis, Insights from Ultra-high Field Imaging in Multiple Sclerosis, Pediatric Multiple Sclerosis: Distinguishing Clinical and MRI Features, and more!