Statistical Modeling in Clinical Trials
Anisimov, Vladimir V. / Fedorov, Valerii V.
Clinical trials at the confirmatory stage of drug development typically require a large number of patients recruited by many clinical centers. The design of multi-center clinical trials consists of several interconnected stages including patient recruitment planning, choosing a randomization scheme and a statistical method for analyzing patient responses on different treatments, and planning the drug supply to satisfy patient demand in differe...