Endothelin in Renal Physiology and Disease
Barton, M. / Kohan, D. E.
Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly, we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, precl...