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The management of psoriatic arthritis (PsA) is complex and early intervention is needed to prevent or delay the progression of the disease. The severity of PsA and response to medication should guide the proper treatment modality, as per the recent EULAR and GRAPPA recommendations. In this collection, the authors begin by examining conventional treatment options include non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-...

In Advances in Medicine and Biology. Volume 128, the authors provide evidence that several families of GPCRs dynamically modulate microglial phenotypes and provide evidence that aberrations in G-protein coupled receptors-mediated signaling are prime contributors to a loss of homeostatic microglia states. A comprehensive landscape on the physiological conditions already known to be important for dendritic cell (DC) differentiation is included. ...

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In this collection, the authors review novel findings strongly suggesting that YS110, a humanized monoclonal antibody with high affinity to the CD26 antigen, represents a promising novel therapy for refractory cancers, immune disorders and MERS-CoV infection. This book show that in vivo administration of YS110 inhibits tumor cell growth, migration and invasion, and enhances survival of mouse xenograft models inoculated with malignant mesotheli...

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In this compilation, the authors open with a discussion on lectins, carbohydrate-binding proteins which are widely present in living organisms and participate in molecular recognition and intracellular functions. Due to their carbohydrate specificity, lectins can be employed as an analytical tool to study glycan structures on glycoconjugates. Plant lectins have also been used to study glycosylation pattern of animal glycoproteins. The first ch...

Advances in Medicine and Biology. Volume 126 opens with a discussion on fungal infections of the central nervous system and the way they have been known to parallel the incidence of systemic fungal infections in at risk populations. The reported percentages of central nervous system involvement associated with invasive fungal infections range from 3% - 100% depending on the species isolated. Next, the authors discuss the effect of agouti-relat...

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In Chapter One, Olga Chub, MD, Ph.D., and Professor Oleksandr V Bilchenko, MD present a study exploring the occurrence of plasmid-mediated resistance genes in gram-negative uropathogens. Next, Chapter Two by Daniela Baconi, Miriana Stan, and Ana Maria Vlasceanu reviews recent knowledge on hallucinogenic drugs. In Chapter Three, recent advances in ultrasound imaging are presented. Following this, Chapter Four by Jinhua Dong, Ph.D., and Hiroshi ...

The chapters in this volume present the latest developments in medicine and biology. The overuse and everyday abuse both in humans and animals, in conjunction with the decreased production of new antimicrobial drugs during the last years, have led to the limitation of the treatment choices and the development of antibiotics resistance as discussed in Chapter One. Chapter Two reports on the overuse of antibiotics as a serious public health prob...

The chapters in this volume present the latest developments in medicine and biology. Chapters One describes the prevalence, anticipated risk factors and potential complications related to ectopic pregnancies. Chapter Two reviews the mechanism participating in altered glucocorticoid sensitivity that in turn affects their effect on immune response. Chapter Three analyzes the usefulness of an initial intravenous immunoglobulin therapy with a dela...

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The chapters in this volume present the latest developments in medicine and biology. Chapters One studies Kleine-Levin syndrome. Chapter Two reviews stress, hypothalamicpituitaryadrenal dysfunction, inflammation, and psychomotor disability in preterm birth infants. Chapter Three discusses the cellular and molecular basis of fibrogenesis. Chapter Four examines the role of ocular melanin, melanosomes and melanocytes in eye functionality. Chapter...

The chapters in this volume present the latest developments in medicine and biology. Chapters One focuses on the synthesis of bisphosphonates and its biomedical applications. Chapter Two reviews polymeric nano-vectors based siRNA delivery. Chapter Three discusses the use of thrombophilia and pharmacological throboprophylaxis screening in women. Chapter Four provides insights into Geobacillus species through an overview of the model strain HTA4...

The chapters in this volume present the latest developments in medicine and biology. Chapters One describes the oxidative stress in disease and health, as well as the action of classic and new antioxidants. Chapter Two examines an investigation by big data analysis of the Urban Heat Island (UHI) effect on human health problems. Chapter Three provides a literature review of the associations between sedentary behaviour and health-related outcome...

The chapters in this volume present the latest developments in medicine and biology. Chapters One discusses the utility of negative pressure therapy in the treatment of chronic resistant venous ulceration by reviewing the current available literature on this topic. Chapter Two reviews telemedicine in chronic respiratory diseases. Chapter Three focuses on the role of GABA/glycine in respiratory network formulation using knock-out mice with resp...

The chapters in this volume present the latest developments in medicine and biology. Chapters One reviews on m-Health in prehospital emergency medicine. Chapter Two analyses regional telemedicine network for the diagnosis and care of cardiac malformations. Chapter Three describes a computational fluid dynamic (CFD) approach with the aim to simulate the flow of blood with cardiac pulse through the aorta artery with aneurysm disease. In Chapter ...

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