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This book uses a rational, science-based approach to explain in plain language that a quantitative view is key for understanding and predicting potentially toxic effects of chemicals.

Alec Bondo, a successful pharmacology professor at a university in New England, makes the shocking discovery that his laboratory has been burglarized and confidential research documents are missing. A famous research scientist dies under mysterious circumstances. Alec and his senior graduate student, Ragini, become entangled in a web of international intrigues, skullduggery, and scientific fraud. Alec fights for his life when he finds out that...

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Incorporating recent advances in molecular biology and examining cellular and molecular mechanisms with regard to toxic effects, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitocho...