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This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug-receptor complexes. This volume offers up-to-date, ...

Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of thi...

The topics analysed cover a broad spectrum of lipid droplets and presents new information in this area of research. The themes analysed include: Lipid droplets as potential antiviral targets, lipid droplets during embryonic development, lipid droplets and their contribution to vldl and chylomicron maturation, important advances in the knowledge of lipid droplets in the last six decades, lipid droplets: structure, composition, formation and fun...

Protein-Lipid Interactions: Perspectives, Techniques and Challenges analyzes and covers a broad spectrum of protein-lipid interactions and presents new information in this area of research. The topics analyzed include: an update on the cholesterol effects of the nicotinic acetylcholine receptor, the modulation of lipid compositions for proteinlipid interactions, membrane dynamics and their structures, defining the moderate affinity of specific...

Food Sources Health Effects and Significance in Biochemistry.

This book presents an overview of membrane organisation and lipid rafts in the cell and artificial membranes. The topics analysed in this book cover a broad spectrum of functions played by lipid rafts in membrane organisation within the cell and artificial membranes, and presents new information in this area of research. The topics analysed include: fluid-mosaic cell membrane structure from cellular control and domains to extracellular vesicle...

During the last four decades, the interest in polyunsaturated fatty acids (PUFA) has augmented manifolds, and the number of published studies is rising each year. The current impetus for this interest has been mainly the observation that PUFA and their metabolites have several physiological roles including: energy provision, membrane structure, cell signalling and regulation of gene expression. In addition, the observation that PUFA are target...

Natural vitamin E includes two groups of closely related fat-soluble compounds, tocopherols and tocotrienols, each composed of four isoforms. α-Tocopherol is a very well-known potent antioxidant and radical scavenger in chemical and biological systems. Its structure has served as template for design and synthesis of more potent antioxidant analogues with regard to its potential protective effect against certain diseases associated with ageing ...

Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of gener...

This book presents an overview of the role in biological processes and health effects produced by indoleamines, which are ubiquitous and versatile molecules with important physiological functions. The topics analysed in this book cover a broad spectrum of functions played by indoleamines including the role of indoleamines in reducing free radical damage and oxidative stress, melatonin, endogenous sources and role in the regulation of fish repr...

This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analysed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state, tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action, sphingolipid diversity, biosynthesis and regulation, metabolism of glycolipids at t...