Regulatory Mechanisms Controlling HIV-1 Induced Immune Ac...
Chase Amanda Jewell
The most widely accepted theory for the massive
depletion of CD4+ T cells in HIV-1 infection
involves depletion of non-infected cells through
immune activation. A specialized cell population,
the T regulatory cells (Tregs), exists to help limit
chronic inflammation by suppressing the immune
activation induced by infectious diseases. We used
an SIV/pigtailed macaque model of HIV-1 disease to
elucidate the role of Tregs in HIV-1-induced ...