Chemistry and Biology of Serpins
Church, Frank C. / Cunningham, Dennis D. / Tollefsen, Douglas M. / Hoffman, Maureane R. / Stone, Stuart R. / Ginsburg, David
Serpins (serine protease inhibitors) are a superfamily of proteins whose physiologi cal action is primarily targeted to inhibiting serine proteases. There are instances where serpins are not inhibitors (and can carry steroid hormones for instance), yet key structural and functional elements found in all serpins are maintained in these 'non-inhibitor' ser pins. Many serpins have well-described biological properties which influence pathophysi...