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The muscular dystrophies are an important group of inherited disorders. They are characterized by muscle wasting and weakness, but vary considerably in their clinical manifestations and severity.This text reviews our understanding of the most important of these disorders. In many instances, the genes and protein products responsible for the dystrophies have been identified and it is now possible to establish a precise diagnosis, detect preclin...

This illustrated and comprehensive historical account deals successively with the early history of muscular dystrophy, refinements of its clinical picture, heterogeneity and the classification and description of the disease, the biochemistry, pathogenesis and the molecular genetics of the disorder and, finally, gene therapy.

Fully revised and updated the new edition of Duchenne Muscular Dystrophy discusses the recent advances in the field of molecular biology for prenatal diagnosis and genetic counselling to the recent pioneering work with anti-sense oligonucleotides, and the possibility of effective RNA therapy.

An extensively updated version of Alan Emerys Introduction to Recombinant DNA, this new edition reflects the major advances in molecular genetics which have occurred in the last decade. Essentially it is a straightforward outline of the general principles and medical applications of molecular genetics which describes experimental techniques in a jargon-free style. Bibliographies and a glossary are provided, and this edition is extensively revi...

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. For sufferers and their family, the illness presents enormous physical and psychological challenges. This new edition answers many of the questions asked about how and why it occurs, and how it affects the life of a recently diagnosed child.