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Techniques for separating cells are needed in many areas of cell biology. This book presents modern methods from the laboratories of experts in the field, and includes tested, reproducible protocols, hints and tips for success, and troubleshooting suggestions. It will be invaluable to a wide range of cell biologists.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking,...

While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppr...

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A chronicle of the history of polar exploration describes the 1991 expedition of a Russian nuclear-powered icebreaker across the polar ice cap and discusses previous expeditions to the North Pole and the explorers who took part.

Lord Hugh Dowding, Air Chief Marshall of the Royal Air Force, Head of Fighter Command, First Baron of Bentley Priory, lived in the grip of unseen spirits. In thrall of the supernatural, he talked to the ghosts of his dead pilots, proclaimed that Hitler was defeated only by the personal intervention of God, and believed in the existence of faeries. How could it be that such a man should be put in charge of evaluating technical developments for ...

The field of melanoma biology has experienced a remarkable surge, owing to progress which has ranged from the basic laboratory/preclinical discoveries to clinical developments. This title brings together some of the leaders who have contributed insights from basic melanoma biology to progress in the clinic.