Bootstrap methods for multi-factorial dose-response designs
Frommolt, Peter![Bootstrap methods for multi-factorial dose-response designs](https://support.digitalhusky.com/media/annotations/sorted/551/5515836/CHSBZCOP035515836.jpg)
Bifactorial designs are used to test for the efficacy of fixed combinations of two (or more) drugs. Researchers are interested in the question if a combination has a significantly higher efficacy than either component drug alone. The power of the existing methods strongly depends on a nuisance parameter representing how much the respective means differ between the groups treated by the component drugs. Furthermore, the methods are only applica...