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Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade -- highlighted by...

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This book summarizes the state-of-the art knowledge on naturally occurring organohalogens, of which more than 3700 are documented. The chapters cover all aspects of this field, including the structural diversity and sources of organohalogens, the mechanisms for their formation and biodegradation, the clinical use of dichloroacetate, and synthesis of the powerful anticancer chlorine-containing cryptophycin. Both biogenic and abiogenic sources o...

Yong-Jin Wu New Indole-Containing Medicinal Compounds Timothy C. Barden Indoles: Industrial, Agricultural and Over-the-Counter Uses Richard J. Sundberg Electrophilic Substitution Reactions of Indoles Tara L.S. Kishbaugh Reactions of Indole with Nucleophiles Erin Pelkey Metalation of Indole Jie Jack Li ∙ Gordon W. Gribble Metal-Catalyzed Cross-Coupling Reactions for Indoles Jeanese C. Badenock Radical Reactions of Indole Fariborz Firoo...

Despite the long association of organohalogen compounds with human activities, nature is the producer of nearly 5, 000 halogen-containing chemicals. Once dismissed as accidents of nature or isolation artifacts, organohalogen compounds represent an important and ever growing class of natural products, in many cases exhibiting exceptional biological activity. Since the last comprehensive review in 1996 (Vol. 68, this series), there have been dis...

-T. L.S. KishbaughMetalation of Pyrrole-K.-S. YeungFurans and Benzofurans -P. E. AlfordLithiation-Based and Magnesation-Based Strategies for the Functionalization of Imidazole: 2001–2010 -L. FuMetalation of Oxazoles and Benzoxazoles -S. Roy • S. Roy • G. W. GribbleMetalation of Pyrazoles and Indazoles -J. C. BadenockMetalation Reactions of Isoxazoles and Benzisoxazoles -Y.-J. WuThiazoles and Benzothiazoles -C. F. NutaitisIsothiazoles and Benzi...

This is the seventeenth annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2004 on most of the important heterocyclic ring systems. The volume opens with two specialized reviews: Dennis Wright covers Furans as Versatile Synthons for Target-Oriented and Diversity-Oriented Synthesis, and John Hepworth and Mark Heron discuss 'The Synthesis and Photochromic Properties of Naphthopyrans'. The remaining ...

-T. L.S. KishbaughMetalation of Pyrrole-K.-S. YeungFurans and Benzofurans -P. E. AlfordLithiation-Based and Magnesation-Based Strategies for the Functionalization of Imidazole: 2001–2010 -L. FuMetalation of Oxazoles and Benzoxazoles -S. Roy • S. Roy • G. W. GribbleMetalation of Pyrazoles and Indazoles -J. C. BadenockMetalation Reactions of Isoxazoles and Benzisoxazoles -Y.-J. WuThiazoles and Benzothiazoles -C. F. NutaitisIsothiazoles and Benzi...

Despite the long association of organohalogen compounds with human activities, nature is the producer of nearly 5, 000 halogen-containing chemicals. Once dismissed as accidents of nature or isolation artifacts, organohalogen compounds represent an important and ever growing class of natural products, in many cases exhibiting exceptional biological activity. Since the last comprehensive review in 1996 (Vol. 68, this series), there have been dis...

Yong-Jin Wu New Indole-Containing Medicinal Compounds Timothy C. Barden Indoles: Industrial, Agricultural and Over-the-Counter Uses Richard J. Sundberg Electrophilic Substitution Reactions of Indoles Tara L.S. Kishbaugh Reactions of Indole with Nucleophiles Erin Pelkey Metalation of Indole Jie Jack Li ∙ Gordon W. Gribble Metal-Catalyzed Cross-Coupling Reactions for Indoles Jeanese C. Badenock Radical Reactions of Indole Fariborz Firoo...