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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. . Volume 7 provides coverage of the latest developments in autophagosome biogenesis an...

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.Considering that autophagy is associated with numerous biological processes, inclu...

Volume 6 provides coverage of the mechanisms of regulation of autophagy, intracellular pathogen use of the autophagy mechanism, the role of autophagy in host immunity, and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability, microRNAs, and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of auto...

With tens of thousands of new CNS tumor cases each year in the US alone, this Book Series is a vital resource for any medical professional encountering brain and CNS neoplasms in their work. Their frequent occurrence, as well as the scope and pace of research in the field, make staying on top of developments a priority. Focusing on the diagnosis, therapy and prognosis of those affecting the spine, this sixth volume in the series on tumors in t...

It is difficult to overstate the potential applications of stem-cell biology to our understanding of, and responses to, disease and injury. This volume aims to bring to its readers authoritative and responsive coverage of aspects of the field that will keep them up-to-date in a fast-moving scientific landscape. The fourth volume in the series on stem cells and their cancer-carrying counterparts, this book sets out the plethora of therapeutic a...

This seventh volume in the Springer’s landmark series of edited books discusses one of the most important subjects in contemporary medicine and scientific endeavors. The volume presents a staggering range of research into medical applications of stem cells and cancer stem cells. While stem cells are essential for normal life of multicellular organisms, including humans, cancer stem cells are a morbid entity having a robust resistance to therap...

The fifth volume in the essential series on stem cell biology provides a detailed explanation of the mechanisms of self-renewing cancer stem cells, as well as their ability to generate the heterogeneous lineages of cancer cells that comprise tumors. It explores the unique resistance of cancer stem cells to conventional chemotherapy techniques able to kill a tumor’s constituent cells. The contents also include a discussion of the myriad applica...

The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and...

This fourth volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis discusses various methodologies for the diagnosis, therapy and prognosis of Colorectal Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included.   This fully illustrated volume: * Presents surgical, radiological, and molecular therapies and prognostic markers for colorectal cancer. * Hi...

This sixth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses Ovarian Cancer, Renal Cancer, Urogenitary Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma. Both standard and emerging therapies for these cancers, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume Identifies biomarkers based on genetic alt...

This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric lo...

Discusses the principles, methods, and applications of immunogold-silver staining (IGSS) to biomedical areas. This work provides a history of IGSS methodolody and IGSS' foundation in biochemical concepts. It covers methods for light microscopy, scanning and transmission electron microscopy, and nonmicroscopical applications of IGSS.

Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an impro...

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating 'toxic assets' and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically int...

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes pediatric medulloblastoma, and treatments including craniospinal...

With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions ...

Histochemistry deals with the activities of chemical components in cells, and immunohistochemistry addresses the function of cell types in tissue or organs, such as those leading to acceptance or rejection of grafts or organs. This book is a methods volume focusing on antigen retrieval, particularly methods used in disease-related antigens. Because the book is a methods volume and a lab manual, it will have an audience of pathologists, biochem...

This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives on the subject, with dedicated sections covering um...

The classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence, for example, , brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain dru...