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Nucleosides are the building blocks for life, they are found in everything from DNA to RNA. This one-step reference is the first comprehensive resource to integrate recent advances within this field. By addressing the topic from different angles it has something for every nucleoside researcher. From the contents: * Biochemistry and Biophysics * Biotechnology * Medicinal Chemistry * Antitumorals and Antivirals Edited by one of the main driving ...

A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The a...

Nucleic acids chemistry has progressed rapidly in the last 10 years with the introduction of many new techniques and the development of many novel therapeutic entities. In Oligonucleotide Synthesis: Methods and Applications, laboratory experts describe in step-by-step detail the powerful new techniques they have developed for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights ...

Dedicated to the fond memory of two great pioneers of this science, Leslie E. Orgel and Stanley L. Miller, this compilation of reviews and original manuscripts provides an overview of the current state of the art, written by some of the eminent "players" in this creative domain of "explorative chemistry". Since we are still far from finding a definitive answer to the most fundamental of questions in science, "chemistry" here is defined in its...