Tetramer Stability and Functional Regulation of Tumor Sup...
Kamada, Rui![Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53](https://support.digitalhusky.com/media/annotations/sorted/126/12696039/CHSBZCOP0312696039.jpg)
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structur...