4 Ergebnisse.

Tuberculosis (TB) remains one of the world's most serious infectious diseases. It is estimated that a third of the world's population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Therefore, we particularly focused on identification of biomarker (s) of infection and the developm...

A study on the effectiveness of alkaloids in Chrysanthemum cinerariifolium on HIV and as an antimycotic done by identifying the 3D structure of ligand molecules using PUBCHEM and 3D structure of receptor molecules using PDB. Chrysanthemum cinerariifolium samples were screened for secondary metabolites like alkaloids, tannins, flavonoids, and terpenoids using GC-MS and showed positive results. ADMET and TOPKAT properties of ligands were carried...

Tuberculosis, a severe bacterial infection is caused by the Mycobacterium tuberculosis and continues to be one of the main causes of morbidity and mortality.A study on the immunological and structural characteristics of a protein belonging to the PPE family of Mycobacterium tuberculosis was done by insilico analysis and reveals that Rv2430c can be used as a possible diagnostic marker for active TB infection. Rv2430c showed statistically signif...

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting ~1% of the worldwide population. Recent biochemical and genetic evidence has strongly suggested that a dysregulated protein arginine deiminase (PAD) activity, in particular protein arginine deiminase 4 (PAD4) contributes to the onset and progression of RA. PAD4 is a transcriptional co-regulator that catalyzes the calcium-dependent conversion of specific arginine residues in pr...