3 Ergebnisse.

Focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. This volume includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture, helping researchers design clinical approaches that can halt tumor growth.

Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal house-cleaning in the cell is called autophagy literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 in yeast. These ATG genes in yeast were the stepping stones to the explosion of researc...

Klionsky (life sciences, U. of Michigan, Ann Arbor) defines "autophagy" as "a process in which the cell typically undergoes membrane rearrangement to sequester a portion of cytoplasm, deliver it to a degradative organelle and recycle the macromolecular constituents." He argues that, in the tradition