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Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic...

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The function of the heart is highly dependent on oxidative energy that is generated in mitochondria. Defects in mitochondrial structure and function can be found in association with cardiovascular diseases. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis...

La presente investigación propone un framework, para el diseño de soluciones de inteligencia de negocio en el sector hotelero, en la misma se procura por integrar los dominios del negocio y tecnológico, lo que contribuye al mejoramiento de la disponibilidad de la información necesaria para el proceso de toma de decisiones. El framework está compuesto por una arquitectura empresarial, un conjunto de indicadores que facilitan el diseño de un cua...

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This book investigates different protocols and architectures that can be used to design, create, and develop security infrastructures by highlighting recent advances, trends, and contributions to the building blocks for solving security issues"--

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Dise...

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology.  The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of di...

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In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antio...

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Esta investigación es el resultado de un trabajo exploratorio, en el Centro Educativo Indígena Cuna Yala de Arquía, ubicado en el municipio de Ungía Choco. Para su construcción se llevo durante varias visitas a la comunidad don la autorización de su máxima autoridad el Saila Anibal Padilla. Este proceso contó con la participación de los padres y madres de familia quienes en la planetaria y en la mola muestran su sabiduría ancestral proveniente...

This book provides a comprehensive analysis of energy risks, energy scenarios and energy policies with special reference to the European Union and its member states, emphasizing the economic and geopolitical dimensions of energy security.

El presente libro trata un problema que en la actualidad aparece en los tribunales de justicia y que no tiene todavía una respuesta legal específica, cual es la temporalidad de la pensión compensatoria. La situación de muchos matrimonios que en la actualidad se separan o se divorcian es muy distinta de la de aquéllos que contempló el legislador cuando llevó a cabo la reforma del Código civil de 7 de julio de 1981. En efecto, la edad, el descen...

Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic...

El presente libro aborda un supuesto de arrendamiento cuyo tratamiento jurídico entraña complejidad, porque al no tener un régimen jurídico específico hay que aplicar el del arrendamiento de cosas, contemplado en el Código civil, con los problemas de adecuación que ello plantea. Esta insuficiencia normativa junto a la frecuencia con que aparece en la práctica hace que el estudio revista el máximo interés, puesto que constituye una guía tanto d...

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease.  An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and ...

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