Pyrrole-Imidazole Alkaloids from Marine Sponges: Structur...
Moldovan, Rares-Petru
Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an improved synthesis would be beneficial. In the present work two different known routes to 8 were investigated. By following the method developed in our group (via Sonogashira coupling) sever...