The Evaluation of New Antiarrhythmic Drugs
Morganroth, J. / Michelson, E. L. / Dreifus, L. S. / Moore, E. Neil Thus, there are now several chronic canine myocardial infarction ventricular tachyarrhythmia models which are available for the evaluation of new antiarrhythmic drugs (Table I). The available models fulfill many, but not all of the requirements for an ideal chronic arrhythmia model (Table 11). The sustained arrhythmias initiated in these models using programmed pacing presumably have the same localized reentrant mechanism that characterizes c...