Concepts, Mechanisms, and New Targets for Chemotherapy
Muggia, Franco M.![Concepts, Mechanisms, and New Targets for Chemotherapy](https://support.digitalhusky.com/media/annotations/sorted/152/15214769/CHSBZCOP0315214769.jpg)
Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with ...