Synthesis and characterization of bioactive molecules der...
P B, Sarode
Terminal alkyne: a versatile synthon for the synthesis of bioactive molecules 1.1 Introduction 1.1.1 History of alkynes Alkynes are one of the fundamental functiohal groups that established the foundation of organic chemistry.l The smallest member of this family, acetylene, was first discovered in 1836 by Edmund Davy.2 ln 1862, Friedrich Wohler discovered the generation of acetylene from the hydrolysis of calcium carbide (Scheme 1). GaC2 + H2O...