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It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently b...

New adventure from A.J. Ponder- in the tradition of The Princess Bride and Terry Pratchett. Sylvalla escapes Avondale castle, and the life of a princess, in search of the adventure she's always wanted. Once found, adventure bites back. Fortunately Sylvalla is not alone - Unfortunately, her new-found companions are less than heroic. Jonathan would rather make money. Dirk would rather live a long and happy life. And at 150, Old Capro would rathe...

A celebration of epic fantasy from award winning and USA TODAY Bestselling author, A.J. Ponder's Prophecy is a read alone novel of power, vengeance, betrayal, and loss-and the second book in the much-loved epic saga The Sylvalla Chronicles Princess Sylvalla has faced dragons, proven herself a hero, and accidentally kidnapped a king. And that kidnapping thing is about to become a problem. Fuming over the indignity of being taken as a hostage, K...

I've seen a thousand futures, a million deaths. Avondale will fall." Sylvalla would rather fight dragons than deal with politics. But as the unexpected queen of two kingdoms, her newfound power is making the neighbouring kings nervous. One by one, the kings fall for Sir Arrant's offers of power and the beguiling butterfly jewels he offers in exchange for their alliance. Determined to save her kingdom, Sylvalla is willing to try anything, in...

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There is no shonage of books on cancer. Why publish another? Simply because the subject is important: possibly the most important challenge facing medicine today, and consequently the focus of one of the faslest-growing areas of fundamental biological research. The quest to understand and control cancer is so absorbing that from time 10 time we really need to pause for a moment and try to take stock of the situation. Given the sheer breadth of...

Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at w...

Many of the most effective treatments for disease have been discovered empir­ ically. Nowadays, however, we think that understanding the biology of a disease will lead us to design better treatments, and to improve the application of treatments we already have. To accomplish this, vast sums are expended on cancer research. Even so, to the casual observer of clinical oncology the proliferation of studies and trials of ever-different combination...