7 Ergebnisse.

Alzheimer's Disease and Advanced Drug Delivery Strategies compiles under a single volume the most recent advances in drug delivery to the brain as related to AD treatment. The book's editors recruited scientists from around the world to produce high quality chapters covering not only nanotechnological approaches, but also microsphere, niosomes, and liposomes. Among the topics covered are synthetic molecules, nobiletin, nose to brain delivery, ...

Keine Beschreibung.

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability.

The physicochemical properties of drugs limit their delivery in terms of absorption, circulation, residence time, and so on, which in turn impacts the pharmacokinetics, pharmacodynamics, toxicity, immunogenicity, and efficacy of these drugs. Various advanced drug delivery systems can overcome such issues and improve therapeutic efficacy. Recent developments in novel drug delivery systems have opened new avenues to providing the safest, most ef...

After oral administration, the majority of drug molecules are absorbed across the small intestine and enter the systemic circulation via the portal vein and the liver. For some highly lipophilic drugs (typically log PN5, lipid solubility 50 mg/g), however, association with lymph lipoproteins in the enterocyte leads to transport to the systemic circulation via the intestinal lymph. The attendant delivery benefits associated with lymphatic drug ...

Interest in Lipid Based Drug Delivery (LBDD) is relatively recent and relates to the developments in the past 10 to 15 years, largely driven by the growing need for novel drug delivery systems to deal with the vast majority of the new chemical entities (NCE) that have poor solubility or permeability, to improve the delivery of existing drugs, and for line extensions. Other applications include drug coating for either taste masking or protectio...

Hot Melt Extrusion can be simply defined as the process of forming a new material by forcing it through an orifice or die under controlled conditions, such as temperature, mixing, feed-rate and pressure. Hot Melt Extrusion is the process of embedding drug in a polymeric carrier. Hot Melt Extrusion is the process of converting a raw material into a product of uniform shape and density by forcing it through a die under controlled conditions. In ...