The Prion Protein
Tatzelt, Jorg![The Prion Protein](https://support.digitalhusky.com/media/annotations/sorted/335/33515391/CHSBZCOP0333515391.jpg)
A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging d...