Gene Delivery to the Blood-Brain Barrier
Thomsen, Louiza Bohn
Drug- and gene delivery to the brain is highly restricted by the vascular barriers of
the brain, denoted by the blood-brain barrier (BBB) and the blood-cerebrospinal
fluid (CSF) barriers. Among these barriers, BBB is the main limiting factor. It is
composed by the brain capillary endothelial cells (BCECs). The BCECs barrier
function is supported by astrocytes, pericytes and neurons to form the blood-brain
barrier. BCECs are very tightly connec...