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This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule ¿magic bullet¿ interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States ¿ from $200 million in 1950 to $1.2 billion in 2010 ¿ has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of r...

Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The development is applied to several infectious diseases that have evolved in response to the world as humans have made it. Many pathogens emerging from ...

This book expands a recent mathematical treatment of the Baars model of individual consciousness to an institutional venue in which multiple ‘Global Workspaces’ cooperate, communicate, and compete. The result is an expansion of Dretske’s necessary conditions communications theory approach to high level cognition, having potential applications ranging from the organizational ecology of the firm to the design and analysis of highly parallel or n...

This book brings together the fundamental ideas of information theory and the statistical mechanics of phase transitions within the context of the neurosciences, culture, immunology and socio-psychological studies. Outlined is a program pertaining to a dynamic and semantic extension of current models for the global neuronal workspace as were previously introduced by Baars, Dretske and others. Topics include original applications of rate distor...

The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecos...

This book brings together the fundamental ideas of information theory and the statistical mechanics of phase transitions within the context of the neurosciences, culture, immunology and socio-psychological studies. Outlined is a program pertaining to a dynamic and semantic extension of current models for the global neuronal workspace as were previously introduced by Baars, Dretske and others. Topics include original applications of rate distor...

A cognitive paradigm for gene expression, via the asymptotic limit theorems of information theory, allows better understanding of how embedding context affects the development of organisms. In sum, epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. The authors show how environmental stressors, in a large sense, can in...

The monograph applies sophisticated topological symmetry tools to biological applications of information theory, along with a Black-Scholes model invocation of the Data Rate Theorem which links information and control theories. The focus is on statistical mechanics and other models that explore pathological phase transitions ¿ driven by changes in available rates of mitochondrial free energy ¿ in physiological functions, a cutting-edge topic i...

This book compiles five papers modeling the effects of neoliberal economics on the emergence of Ebola and its aftermath. The multidisciplinary teams represented here place both Ebola Makona, the Zaire Ebola virus variant that has infected 28, 000 in West Africa, and Ebola Reston, which is currently emerging in industrial hog farms in the Philippines and China, within a multi-plank modeling framework. This volume proposes an alternate science o...

The book is a unique exploration of a spectrum of unexpected analogs to psychopathologies likely to afflict real-time critical systems, written by a specialist in the epidemiology of mental disorders. The purpose of this book is to develop a set of information-theoretic statistical tools for analyzing the instabilities of real-time cognitive systems at those varying scales and levels of organization, with special focus on high level machine fu...

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a pers...

Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The authors apply the new formalism toward characterizing a number of infectious diseases that have evolved in response to the world as human...

A frightening study of the way misguided and malevolent social policy can spark a chain reaction of enormous and unforeseen urban collapse.