14 Ergebnisse.

As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its pred...

This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates re...

The authors examine previously observed concepts of early aging and death, such as socioecomic stresses and health inequalities, to state-level populations and survey in detail the grinding pressures of steep economic, social, and political hierarchy on hundreds of millions of people.

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This book discusses the socioeconomic effects of Right-to-Work (RTW) laws on state populations. RTW laws forbid requiring union membership even at union-represented worksites. The core of the 22 long-term RTW states was the Confederacy, cultural descendants of rigidly hierarchical agrarian feudal England. RTW laws buttress hierarchy and power imbalance which unions minimize at the worksite and by encouraging higher educational attainment, soci...

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This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a pers...

This book discusses the socioeconomic effects of Right-to-Work (RTW) laws on state populations. RTW laws forbid requiring union membership even at union-represented worksites. The core of the 22 long-term RTW states was the Confederacy, cultural descendants of rigidly hierarchical agrarian feudal England. RTW laws buttress hierarchy and power imbalance which unions minimize at the worksite and by encouraging higher educational attainment, soci...

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule ¿magic bullet¿ interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States ¿ from $200 million in 1950 to $1.2 billion in 2010 ¿ has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of r...

Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The development is applied to several infectious diseases that have evolved in response to the world as humans have made it. Many pathogens emerging from ...

A cognitive paradigm for gene expression, via the asymptotic limit theorems of information theory, allows better understanding of how embedding context affects the development of organisms. In sum, epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. The authors show how environmental stressors, in a large sense, can in...

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a pers...

Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The authors apply the new formalism toward characterizing a number of infectious diseases that have evolved in response to the world as human...

A frightening study of the way misguided and malevolent social policy can spark a chain reaction of enormous and unforeseen urban collapse.