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This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and/or chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as to fulfill regulatory obligatio...

This book reviews the use of supercritical fluid chromatography (SFC) in drug discovery and describes its application in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products, its use in pilot-scale operations as a chromatographic technique, and the advancement of SFC with new technologies.