Effects of Demethylation on the Expression of Foxp3 in T-...
Yao, Edmund![Effects of Demethylation on the Expression of Foxp3 in T-reg Cells](https://support.digitalhusky.com/media/annotations/sorted/158/15887805/CHSBZCOP0315887805.jpg)
CD4+Foxp3+ regulatory T cells (TREG) are pivotal in the maintenance of immune tolerance to self-antigens and act as regulators of autoimmune reactions. There are two subsets of TREG: naturally occurring (nTREG) which develop in the thymus and inducible (iTREG) which are generated from conventional Foxp3- effector T cells (TCONV) in the periphery or in vitro. While both subsets require Foxp3 expression to function, iTREG cells gradually downreg...