The Role of Regulatory T Cells in Bone Homeostasis
Zaiss, Mario
In summary, our data open a new perspective in the interaction between the immune system and the skeleton. The central concept of osteoimmunology that inflammatory T cell subsets such as activated Th1 cells and Th17 cells drive bone loss is now enriched by the concept that immune homeostasis is tightly linked to bone homeostasis. Thus, a key mechanism of immune regulation, the naturally occurring Foxp3+ regulatory T cells, transduces its favou...