138 Ergebnisse - Zeige 61 von 80.

Candida species are important human pathogens that are best known for causing opportunist infections in immunocompromised hosts (e.g. transplant patients, AIDS sufferers, cancer patients). Infections are difficult to treat and can be very serious. 30-40% of systemic infections result in death. The sequencing of the genome of C. albicans and those of several other medically-relevant Candida species has provided a major impetus for Candida compa...

As bacterial antibiotic resistance continues to exhaust the supply of effective antibiotics, a global public health disaster appears likely. Poor financial investment in antibiotic research has exacerbated the situation. A call to arms - raised by several prestigious scientific organizations a few years ago - rallied the scientific community and now the scope of antibacterial research has broadened considerably. Multi-disciplinary approaches h...

Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.

Microorganisms that convert gaseous nitrogen (N2) to a form suitable for use by living organisms are pivotal for life on Earth. Another set of microbial reactions utilize the bio-available nitrogen creating N2 and completing the cycle. This crucial nutrient cycle has long been the subject of extensive research, and recent advances - in studying the biochemistry, bioinformatics, cell biology, and the physiology of bacterial nitrogen cycling pro...

The genus Clostridium represents a heterogeneous group of anaerobic spore-forming bacteria, comprising prominent toxin-producing species, such as C. difficile, C. botulinum, C. tetani and C. perfringens, in addition to well-known non-pathogens like solven

Flagella-dependent motility is widespread throughout prokaryotes and is advantageous when nutrients are limited as a mechanism to migrate to more favorable environments and to compete with other micro-organisms. Flagella systems can also play an important

World renowned scientists critically review the most important issues in this rapidly expanding field.

In recent years there have been tremendous achievements made in DNA sequencing technologies and corresponding innovations in data analysis and bioinformatics that have revolutionized the field of genome analysis. In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generat...

Biodegradation of aromatics, molecular detection, predictive modelling, regulatory networks, bioavailability, chemotaxis, transport, functional genomics, and much more.

The genus Acinetobacter is a group of Gram-negative, non-motile and non-fermentative bacteria belonging to the family Moraxellaceae. They are important soil organisms where they contribute to the mineralisation of, for example, aromatic compounds. Acinetobacter are able to survive on various surfaces (both moist and dry) in the hospital environment, thereby being an important source of infection in debilitated patients. These bacteria are inna...

Mollicutes are a class of simple bacteria characterized by the lack of a bacterial cell wall and their very small genomes (580 kb to 2200 kb). This phylogenetically coherent group contains a broad range of different plant and animal pathogens making it an ideal model for understanding gene function, gene regulation and the evolution of virulence factors in other bacterial pathogens. The recent development of improved tools for manipulating mol...

Pasteurellaceae comprise a large and diverse family of Gram-negative bacteria, with members ranging from important pathogens such as Haemophilus influenzae to commensals of the animal and human mucosa. Information on the biology of these organisms has mus

Systems biology is the study of the dynamic interactions of more than one component in a biological system in order to understand and predict the behavior of the system as a whole. Systems biology is a rapidly expanding discipline fuelled by the 'omics' era and new technological advances that have increased the precision of data. A focus on simple single cell organisms, such as bacteria, aids tractability and means that systems microbiology is...

Approaches to the teaching of veterinary parasitology face two major challenges. First, the quantity of data describing any given parasite can be overwhelming, if not indigestible, for students. Second is the urge to write more and more about less and less, which is the bane of those who write textbooks intended to be used by students. To meet these challenges the editors of this volume have opted to be selective in the choice of topics in an ...

Since their discovery in the 1960s, methicillin-resistant S. aureus (MRSA) strains continue to present unique challenges to clinicians, microbiologists, and molecular biologists around the world. These organisms are typically resistant to several other antimicrobial agents, including aminoglycosides, chloramphenicol, clindamycin, fluoroquinolones and macrolides and are susceptible only to vancomycin. In fact there is increasing evidence that t...

Rhabdoviruses are a diverse family of single stranded, negative sense RNA viruses that can successfully utilize a myriad of ecological niches, ranging from plants and insects, to fish and mammals. This virus family includes pathogens such as rabies virus, vesicular stomatitis virus and potato yellow dwarf virus that are of tremendous public health, veterinary, and agricultural significance. Due to the relative simplicity of their genomes and m...

Salmonellae are important pathogens, responsible for an estimated one million deaths and 100 million human infections annually. Their genomes are mosaic puzzles, results of lateral transfer events that occur within a stable genetic background. Extraordinary diversity of host ranges and pathogenicity traits between different strains are the consequence of both specific genome insertions/deletions and minute changes in genome composition. Genomi...

Streptomycetes are unusually complex bacteria that are abundant in soil. They grow as branching filaments and form chains of spores. Most importantly, they have an extraordinary ability to make antibiotics, for which they are the main industrial source, as well as other metabolites with medicinal properties. In recent years, the search for new antibiotics and other drugs in streptomycetes has been augmented by genomic studies, genome mining, a...

Small DNA tumour viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus and the papillomavirus families. These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control and tumour formation. The causal link between papillomaviruses and some human cancers is well known and a role for polyomavirus in human cancer has recently been established. Aden...

An international panel of leading staphylococcal researchers provide a state-of-the art overview of the field. Essential reference source.