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This volume summarizes the proceedings of two workshops sponsored by the Bill and Melinda Gates Foundation on cutting edge systems and synthetic biology research which could facilitate mitigation and adaptation through quantum leaps in photosynthesis, fertilization, methane control, and drought and disease resistance, and thereby substantially increase crop yield and soil carbon. The technologies are at various stages of development--some are ...

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This book is about the history of emerging new therapies and preventions for a host of human diseases via biotechnology, the science that drives it and the people and companies who transformed that science into the biotechnologies we benefit from"--

This book provides a road map for such analysis. Advice and practical guidance are provided, starting with the planning stages of gene targeting, CRISPR-Cas gene editing, or mutagenesis experiments, through the complete analysis of complex phenotypes, including tips on breeding strategies, studying dominant mutations, and characterizing a mutant mouse with no apparent phenotypic abnormalities.

The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--

Grounds for Knowledge is an engaging and knowledgeable guide to CSH Laboratory's buildings both historic and new, and to the 150 species of trees that surround them. The superb color photography and detailed maps invite exploration of the newly designated Bungtown Botanical Garden. Buildings and landscapes of nearby Lab campuses in Woodbury, Lloyd Harbor, and Cold Spring Harbor are covered as well.

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To the casual onlooker, it took just 10 months to apply a revolutionary new technology to develop a vaccine against COVID-19. Messenger RNA (mRNA), the long-chain molecule at the heart of these vaccines, is now regarded as something of a global savior. What most people don't know, however, is that this technology had been in the works for three frustrating decades. Even before that came 30 more years of fundamental research, setting the stage ...

Advances in medicine have made possible better treatments for widespread, familiar human illnesses like cancer, diabetes, and heart disease. Yet there are thousands of much less common diseases, most of genetic origin, each classed as "rare" because it afflicts only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an ...

The retina is a layer of neural tissue that lines the inner eye and captures visual stimuli. This volume provides an update on retinal diseases, describing the genetic and pathophysiological basis of the diseases and advances in strategies to treat them"--

Written and edited by experts in the field, this collection provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER.