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Clinical trials at the confirmatory stage of drug development typically require a large number of patients recruited by many clinical centers. The design of multi-center clinical trials consists of several interconnected stages including patient recruitment planning, choosing a randomization scheme and a statistical method for analyzing patient responses on different treatments, and planning the drug supply to satisfy patient demand in differe...

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Originally presented at the Second International Workshop on the Application of X-ray Computed Tomography (CT) for Geomaterials held in Aussois, France, in October 2006, this collection of essays from 48 contributors covers a wide range of topics--from fundamental characterization of material behavior to applications in geotechnical and geoenvironmental engineering--and are useful for studying a wide range of materials, including rock, bone, c...

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The work presented here illustrates, using the heavily utilized free software NetLogo, the main principles of agent-based spatial simulation. It will provide theoretical and conceptual backgrounds as well as algorithmic and technical insights, including code and applets, so that readers can test and re-use most of its content.

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Constrained optimization is a challenging branch of operations research that aims to create a model which has a wide range of applications in the supply chain, telecommunications and medical fields. As the problem structure is split into two main components, the objective is to accomplish the feasible set framed by the system constraints. The aim of this book is expose optimization problems that can be expressed as graphs, by detailing, for ea...

This book focuses on a particular class of models (namely Multi-Mechanism models) and their applications to extensive experimental data base related to different kind of materials. These models (i) are able to describe the main mechanical effects in plasticity, creep, creep/plasticity interaction, ratcheting extra-hardening under non-proportional loading (ii) provide local information (such us local stress/strain fields, damage, ....). A parti...

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The book is devoted to a modern section of the probability theory, the so-called theory of branching random walks. Chapter 1 describes the random walk model in the finite branching one-source environment. Chapter 2 is devoted to a model of homogeneous, symmetrical, irreducible random walk (without branching) with finite variance of the jumps on the multidimensional integer continuous-time lattice where transition is possible to an arbitrary ...

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This text introduces the principles of routing protocols and metrics as they affect wireless networking environments, specifically in urban areas. Timely because of the recent rise in small city life, this topic includes the consideration of ad hoc, mesh, vehicular, sensor, and delay tolerant networks. These approaches are each unique, and author Miguel Mitre Campista provides a thorough, but accessible, explanation of their individual charact...

Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aim to cover a wide range of topics in this area.

The persistence of noise in imaging technologies has been one of the greatest challenges to the developments of digital imaging technologies in modern medicine, such as MRIs. This text conveys the usefulness of wavelets in compact signal and image representations to denoise images and improve compression and feature detection processing. Standard imaging techniques are largely successful in modern medical practices, and denoising only aids the...

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