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In 1628 William Harvey published his discovery of the existence of the microcirculation which he deduced from careful anatomical and physiological study. Thirty-three years later, Malpighi confirmed the presence of capillaries through direct microscopical observation. Subsequent scientific advance has been slow, and in view of the fact that microvascular in the genesis and expression of many pathophysiology may be implicated diseases, our know...

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By now it has become obvious that Federal Reserve actions have an immense impact on the functioning of our economy. As a result, a great deal of research has been done on the Fed and on monetary policy. Much of this work is normative, it tells us what the Fed should do. Positive work on the Fed has usually tried to elucidate particular Fed policies, and has not tried to present a theory of why the Fed behaves the way it does. The dominant theo...

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This NATO Advanced Research Workshop was devoted to the pre­ sentation, evaluation, and critical discussion of numerical methods in nonrelativistic and relativistic hydrodynamics, radia­ tive transfer, and radiation-coupled hydrodynamics. The unifying theme of the lectures was the successful application of these methods to challenging problems in astrophysics. The workshop was subdivided into 3 somewhat independent topics, each with their own ...

The methodology of drug development has been the subject of extensive dis­ cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs. The Chemotherapy Program of the National Cancer In­ stitute has represented the major focus of initial efforts in drug development, as summarized in the historical perspective presented in chapter 1 a...

Circuit simulation has been a topic of great interest to the integrated circuit design community for many years. It is a difficult, and interesting, problem be­ cause circuit simulators are very heavily used, consuming thousands of computer hours every year, and therefore the algorithms must be very efficient. In addi­ tion, circuit simulators are heavily relied upon, with millions of dollars being gambled on their accuracy, and therefore the ...

During the 25 years since acute coronary care was focused into Coronary Care Units there have been three major Phases: I. prevention of death caused by arrhythmias, II. prevention of death due to myocardial failure, and III. limitation of infarct size. In the latter two Phases, there has been infringement upon the time honored concept of a prolonged period of rest for the patient in general and the heart in particular to minimize myocardial me...

Stafford reflects on the writing process and on the influences on his art

This book is a direct result of the NATO Advanced Study Institute held in Banyuls-sur-mer, France, June 1985. The Institute had the same title as this book. It was held at Laboratoire Arago. Eighty lecturers and students from almost all NATO countries attended. The purpose was to review the state of the art of physical oceanographic numerical modelling including the parameterization of physical processes. This book represents a cross-section o...

viii blems as the study of catalytic chemical reactions in the laboratory scale, quantum optics, hydrodynamic instabilities, or large scale phenomena of interest in physics, geology, atmospheric dynamics and climatology. We expect that the present Volume will acquaint researchers and advanced students in geosciences with the concepts and tools of dyna­ mical systems and will thus serve as a jumping off point for new developments and new points...

A tercentenary conference of March, 1985, drew to Newport, Rhode Island, nearly all the most distinguished Berkeley scholars now active. The conference was organized by the International Berkeley Society, with the support of several institutions and many people (whose help is acknowl­ edged below). This volume represents a selection of the lead papers deliv­ ered at that conference, most now revised. The Cartesian marriage of Mind and Body has...

Economists, decision analysts, management scientists, and others have long argued that government should take a more scientific approach to decision making. Pointing to various theories for prescribing and rational­ izing choices, they have maintained that social goals could be achieved more effectively and at lower costs if government decisions were routinely subjected to analysis. Now, government policy makers are putting decision science to...

In Dutch "WISKOBAS" stands for a particular kind of mathematics in the elementary school (ages 6-12). In tum Wiskobas was one of the depart­ ments in the IOWO, the Institute for the Development of Mathematics Education. This institute was concerned with the development of material for mathematics education as well as the related research on the possibility of change from the then existing arithmetic instruction to the future mathematics educat...

Recently I taught short courses on functional equations at several universities (Barcelona, Bern, Graz, Hamburg, Milan, Waterloo). My aim was to introduce the most important equations and methods of solution through actual (not artifi­ cial) applications which were recent and with which I had something to do. Most of them happened to be related to the social or behavioral sciences. All were originally answers to questions posed by specialists ...

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Medicine, morals and money have, for centuries, lived in uneasy cohabitation. Dwelling in the social institution of care of the sick, each needs the other, yet each is embarrassed to admit the other's presence. Morality, in particular, suffers embarrassment, for it is often required to explain how money and medicine are not inimical. Throughout the history of Western medicine, morality's explanations have been con­ sistently ambiguous. Pla.o h...

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