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This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many...

The main focus of this monograph on whistled speech is the result of a worldwide inquiry primarily based on the author’s unprecedented fieldwork and laboratory experience. The different questions raised by the origin and the evolution of whistled forms of languages are also explored, including the role of environmental constraints in the emergence of whistled speech, their phonetic and phonological typology, the cognitive processing of whistle...

The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an ...

This book, written by leading investigators, brings together the latest knowledge about key aspects of the most rapidly progressing fields of tumor escape and tumor resistance to CTL. Readers will benefit from a collection of outstanding surveys that cover some factors regulating resistance to CTL cytotoxicity, the influence of tumor microenvironment, and the resistance to death ligands, mediated apoptosis, and means to reverse resistance. Thi...

This volume explores the ethical questions that arise in the development, creation and use of robots that are capable of semiautonomous or autonomous decision making and human-like action. It examines how ethical and moral theories can and must be applied to address the complex and critical issues of the application of these intelligent robots in society.Coverage first presents fundamental concepts and provides a general overview of ethics, ar...

Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous ...

The book presents the processes governing the dynamics of landscapes, soils and sediments, water and energy under different climatic regions using studies conducted in varied climatic zones including arid, semi-arid, humid and wet regions. The spatiaotemporal availability of the processes and fluxes and their linkage to the environment, land, soil and water management are presented at various scales. Spatial scales including laboratory, field,...

This text covers topics in algebraic geometry and commutative algebra with a strong perspective toward practical and computational aspects. The first four chapters form the core of the book. A comprehensive chart in the preface illustrates a variety of ways to proceed with the material once these chapters are covered. In addition to the fundamentals of algebraic geometry—the elimination theorem, the extension theorem, the closure theorem, and ...

This volume is about the social identities of young Indigenous people in contemporary Australia, based on fieldwork in the rural community of Yarrabah, in Queensland. This case study of Yarrabah is based on seventeen ethnographic interviews with women and men in their twenties.  With the aim of exploring how diverse social discourses have influenced the social identities of young Indigenous people in contemporary Australia, this book represent...

This first-of-its-kind reference moves the concepts and methodologies of game analytics and learning analytics into the emerging field of serious games. The book calls for more validated and standardized research into serious games analytics, backing up this demand with ways that player data can be transformed into information of value to the academic and serious games sectors. Featured methodologies derive from diverse disciplines, from compu...

This book is a well-illustrated, clearly written guide to the iatrogenic effects of orthodontic treatment that provides practical information on orthodontic diagnosis, treatment planning, and post-treatment retention and highlights preventive measures to avoid complaints and lawsuits. It is divided into three parts, focusing on white spot lesions, periodontal deterioration, and external apical root resorption (EARR). In the first part, the rea...

Nanotechnology has already demonstrated surprising potential for improving the performance of construction materials, and many of these recent developments were facilitated by NICOM symposia. The NICOM5 proceedings will cover the emerging opportunities and future use of nanotechnology in construction, and will illustrate the broad potential for application of nanotechnology to challenging problems involving materials and infrastructure.

This book covers novel research results for process and techniques of materials characterization for a wide range of materials. The authors provide a comprehensive overview of the aspects of structural and chemical characterization of these materials.  The articles contained in this book covers state of the art and experimental techniques commonly used in modern materials characterization. The book includes theoretical models and numerous illu...

In the late 18th century explorers and scientists started venturing into the Arctic in a heroic and sometimes deadly effort to understand and unveil the secrets of the unforgiving and mysterious polar region of the high north. Despite that the Arctic was already populated mattered less for the first wave of polar researchers and explorations who nevertheless, brought back valuable knowledge. Today the focus in Arctic science and discourse has ...

Th is book covers research design and methodology from a unique and engaging point of view, based on accounts from infl uential researchers across the fi eld of Criminology and Criminal Justice.Most books and articles about research in criminology and criminal justice focus on how the research was carried out: the data that were used, the methods that were applied, the results that were achieved. While these are all important, they do not pres...

Some of the most recent and significant results on homomorphisms and derivations in Banach algebras, quasi-Banach algebras, C*-algebras, C*-ternary algebras, non-Archimedean Banach algebras and multi-normed algebras are presented in this book. A brief introduction for functional equations and their stability is provided with historical remarks. Since the homomorphisms and derivations in Banach algebras are additive and R-linear or C-linear, th...

This book explores the nature of pregnancy and metabolic syndrome as proinflammatory conditions and explains how pregnancy provides a window of opportunity for preventing the lifelong complications of metabolic syndrome, during which key risk factors can be identified and beneficial dietary changes can be implemented. The book’s opening sections discuss inflammation in the context of pregnancy, including the nature of the placenta as a proinfl...

This concise, easy-to-read book summarizes the current clinical evidence and basic science relating to aging and the skin, assisting the clinician in addressing skin problems in older dermatologic patients. Each chapter focuses on a particular area in which new knowledge has rapidly emerged over the past 5 years, ensuring that the book is completely up-to-date.  Recent insights into aging skin from basic and translational science are first dis...

This book highlights the current understanding of materials in the context of new and continuously emerging techniques in the field of electron microscopy.  The authors present applications of electron microscopic techniques in characterizing various well-known & new nanomaterials. The applications described include both inorganic nanomaterials as well as organic nanomaterials.

This book analyzes what is currently known about functional and ecological xylem anatomy. In addition to serving as a source of information to professionals, instructors, and advanced students in plant science and forestry, the inherent beauty of xylem that is apparent in many images will be a source of inspiration to readers who are not yet familiar with the topic. This work offers a unique combination of scientific insight based on thorough ...