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The second edition of this well-received volume has been revised and updated to reflect the  advances in pathological classification and molecular epidemiology of diffuse low-grade gliomas (DLGG) in adults and offers an updated review on individualized therapies. This book presents the latest research pertaining to the diagnosis, genetics, therapy and management of DLGGs.  It extensively covers recent research on the natural history of DLGGs a...

Based on a fundamental understanding of the interaction between bacteria and materials, this timely volume emphasizes the latest research in the antimicrobial interfacial design and provides an invaluable blueprint for improving antimicrobial performance on devices and products. Antimicrobial Coatings and Modifications targets reduction of microbial accumulation on biomedical and industrial materials through changing interfacial characteristic...

This book focuses exclusively on the surgical patient and on the perioperative environment with its unique socio-technical and cultural issues. It covers preoperative, intraoperative, and postoperative processes and decision making and explores both sharp-end and latent factors contributing to harm and poor quality outcomes. It is intended to be a resource for all healthcare practitioners that interact with the surgical patient. The first sect...

Offering a concise and multidisciplinary reference guide to the state of the art in Australian operations research, this book will be of great value to academics working in many disciplines associated with operations research, as well as industrial practitioners engaged in planning, scheduling and logistics.Over 60 papers, with topics ranging from academic research techniques and case studies to industrial and administrative best practices in ...

Foodborne illnesses continue to be a major public health concern.  All members of a particular bacterial genera (e.g., Salmonella, Campylobacter) or species (e.g., Listeria monocytogenes, Cronobacter sakazakii) are often treated by public health and regulatory agencies as being equally pathogenic, however, this is not necessarily true and is an overly conservative approach to ensuring the safety of foods.  Even within species, virulence factor...

Covering anatomical, clinical, pathological and laboratory aspects of surgical histopathology specimens,  this revised, updated third edition relates specimen dissection and its clinical context to relevant histopathology reports, and therefore a more comprehensive patient prognosis and management is possible.This book explains pathological and clinical terminology, including a glossary of clinical request form abbreviations. A standardised st...

This book aims to provide a guide for urodynamic investigation in individuals who have suffered spinal cord injuries. It is universally acknowledged that this type of investigation is valuable and most international guidelines consider it mandatory in patients with neurogenic bladder dysfunction. The book offers an evidence based knowledge of applicability, clinical value, and limitation, and will give the reader strong diagnostic outcomes th...

This volume addresses an urgent need across multiple disciplines to broaden our understanding and use of response processes evidence of test validity. It builds on the themes and findings of the volume Validity and Validation in Social, Behavioral, and Health Sciences (Zumbo & Chan, 2014), with a focus on measurement validity evidence based on response processes. Approximately 1000 studies are published each year examining the validity of infe...

This book describes the structures and functions of active protein filaments, found in bacteria and archaea, and now known to perform crucial roles in cell division and intra-cellular motility, as well as being essential for controlling cell shape and growth. These roles are possible because the cytoskeletal and cytomotive filaments provide long range order from small subunits. Studies of these filaments are therefore of central importance to ...

The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates regarding pathogenesis, clinic features, and management, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition...

This book provides readers with a thorough review on cervical cancer, treatment guidelines and emerging therapies available for the disease. It reviews the epidemiology clinical features, diagnosis, and medical management of cervical cancer.Given the increasing need for preventive strategies, treatment optimization with collaborative and integrative work, this book improves the actual and integral knowledge in this neoplasm. Given the high pre...

Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters...

This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal boo...

This text is designed to present a comprehensive and state-of the-art approach to the current and future status of POEM. Sections address preliminary issues faced by surgeons and gastroenterologists who are interested in implementing this procedure into their treatment armamentarium. These areas include the evolution of the technique, training and credentialing, as well as tools and platforms commonly used for POEM. Subsequent chapters focus o...

This book, now in an extensively updated and expanded third edition, offers important insights into polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), providing an overview of their pathophysiology, genetics, immunology, and endocrinological mechanisms but above all presenting the state of the art in diagnosis and treatment.  Both PMR and GCA are diseases of advanced age. Early diagnosis and treatment can save one of the most preciou...

This comprehensive teaching atlas covers virtually all pancreatic anatomy (including variants) and diseases in a pattern-based radiologic approach. Cases are presented as “unknowns”, allowing the reader to analyze the findings and learn key points. Each teaching case includes a brief clinical history, images, a description of imaging findings, differential diagnoses, final diagnosis with images of gross pathology, and a discussion of key teach...

The first volume of a pair that charts relation algebras from novice to expert level, this text offers a comprehensive grounding for readers new to the topic. Upon completing this introduction, mathematics students may delve into areas of active research by progressing to the second volume, Advanced Topics in Relation Algebras, computer scientists, philosophers, and beyond will be equipped to apply these tools in their own field. The careful p...

This indispensable text/reference presents a comprehensive overview on the detection and prevention of anomalies in computer network traffic, from coverage of the fundamental theoretical concepts to in-depth analysis of systems and methods. Readers will benefit from invaluable practical guidance on how to design an intrusion detection technique and incorporate it into a system, as well as on how to analyze and correlate alerts without prior in...

​This book is the first of its kind to describe ocular manifestations of systemic diseases in the pediatric population. Written and edited by experts in areas of pediatric ophthalmology and genetics, this new text covers a multitude of topics in a comprehensive and cataloged fashion. The Eye in Pediatric Systemic Disease is designed as an in-depth and up-to-date reference work that is heavily referenced, thus allowing the reader ready access t...

With the expertise of an author panel of leading clinicians in the field of surgery, trauma, critical care and geriatrics the new edition of this text addresses the explosion in knowledge on the impact aging has on injury, acute illness and critical care management. The text covers the physiologic changes associated with aging, as well as the clinical assessment, stratification, and management of acute illness and injury. Furthermore, the new ...