Herbal drugs have a great medicinal and huge growth potential world-wide. Herbal drugs obtained from plants and herbs are extensively used in the cure of various human ailments since ancient era. Traditionally, different parts of neem were used in the treatment of leprosy, ulcers, cough and ring worm. So, my present research is going to explore the Anxiolytic and Antidepressant potential of hydro-alcoholic leaves extract of Neem. In conclusion, it demonstrated a significant pharmacological potency against psychiatric disorders.