This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include mesenchymal stem cells and Type 1 Diabetes Mellitus, recent advances in scleroderma pulmonary fibrosis, major histocompatibility complex, HDL quantity and quality in HIV, surgical management of chronic thromboembolic pulmonary hypertension, patient safety in radiation treatment, telemedicine as an effective tool for the management of maxillofacial pathology, and biological agents in inflammatory eye disease.