Featuring contributions from leading experts, this book presents an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. Discussion includes the behavioral strategies and characteristics of addiction as well as the mechanistic approaches to understanding the underlying neurobiology. The authors provide information from mathematical models, model organisms, and traditional, well-characterized animal models, and experiments conducted in humans. They deliver a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.