Extraterrestrials from the planet Infinite in the Andromeda Galaxy land their spaceship near the home of the Bopper family: five ladybugs in Missionville, Texas. The extraterrestrials recruit the ladybugs to be part of their mission to save children dying from a virus in the town of Hopeville, Texas. Through their own trained robots, the aliens equip the ladybugs with a microchip containing the virus's cure to be transported to the children's hospital. Though humans are puzzled by the aliens' advanced technology and visionary gifts, they join forces with robots, and the ladybugs battle evil and danger with optimism and hope.