Topics in this clinically focused publication devoted to Anticoagulants are: Antithrombin clinical applications and anti-inflammatory effects, Pharmacology and laboratory testing of oral direct thrombin inhibitor Dabigatran, Pharmacology and laboratory testing of the oral Xa inhibitors, Clinical use of the new oral anticoagulants, Pharmacology and safety of new oral anticoagulants-the challenge of bleeding, Emergency reversal of Warfarin anticoagulation - prothrombin complex concentrate compared with plasma, Prothrombin complex concentrate as reversal agent for new oral anticoagulants - lessons from prelinical models, Bleeding with new oral anticoagulants - clinical presentation and management, Treatment of ICH with new oral anticoagulants - a neurologist's view, Management of anticoagulation agents in trauma patients, and Anticoagulation and pediatric patients.