The proposed book will be a multi-author review book comprised of relevant chapters written in the form of critical reviews by the leading researchers in their respective fields. The format of the articles will be in semi-academic style in which research data from various experimental systems will be presented while focusing on their applications in human beings with respect to the prevention and treatment of age-related impairments in brain functions. The book will consist of about 18 chapters, each of which will be on an average 16 pages long giving about 300 pages. Each chapter will be a comprehensive and critical review of the topic in question presenting important data in a tabulated form, and wherever necessary using photographs and line drawings. It will provide an authoritative and up-to-date account of a specific topic with a comprehensive list of citations of original research papers and review articles.