Structure-soil interaction is a subject currently receiving close attention from researchers in a wide range of research centers, mainly concerned with practical applications. In current design practice, structural engineers usually disregard any influence that the settlement of the supporting ground may have on the response of framed structures. Likewise, in foundation design, analysis of actual settlements is carried out with no assessment of the effect of the stiffness of the structure. A detailed review of literature culminated to take up an investigation on the building frames founded on pile groups. The total investigation has been carried out in three phases. The response of the building frame is evaluated in terms of displacements, rotations, shear forces and bending moments. The frame which is used for the study is also analyzed with the fixed bases to compare the behavior of the frame with and without soil interaction.