Value chains of bio-based chemicals are very complex. Hence, a strategic decision support tool for bioeconomic site and logistics planning is developed. It includes an integrated model and three sub-models: optimization for the locations and capacities of pretreatment plants, technical for technical and economic evaluations, risk for the evaluation of uncertainties. As a result, the model suggests a nearly optimal location and the associated logistic network for the production of biochemicals.This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.