Dental materials in the oral cavity are exposed to saliva and when they are removed salivary components may remain on the surface. Because submandibular-sublingual saliva promotes the adhesion of microorganisms to poly methyl methacrylate, it may also mediate adhesion of oral epithelial cells and leukocytes to the resin prostheses. These epithelial cells would be present adhering to the resin prostheses and DNA could be extracted from the epithelial cells. In the present study we isolated epithelial cells from resin prostheses and analyzed the DNA for sex determining region Y (SRY) and its use in determining the sex of the individual.