This volume details protocols emphasizing systems-level approaches for the characterization of DNA-protein interactions. Chapters detail current genomic strategies, techniques optimized for in vivo systems, as well as imaging-based and single-molecule methods. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, contains tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.Authoritative and cutting-edge,  DNA-Protein Interactions: Methods and Protocols aims to present high-throughput techniques that will complement biochemistry-based protocols to aid researchers in their studies.