This book explores the increasingly broad terrain of drugs in American society with an emphasis on politics. It begins with the War on Drugs initiated by President Richard Nixon in the early 1970s and extends to the current day with the vast power of the pharmaceutical industry (Big Pharma), expansion of global criminal syndicates, militarization of the drug war, and struggles between states and federal government over the legalization of marijuana. This book explores the long historical trajectory of both the War on Drugs and the growth of Big Pharma, focusing on social outcomes and political consequences in the US and beyond.