Excerpt from The Dublin Journal of Medical Science, Vol. 100: Containing Original Communications, Reviews, Abstracts, and Reports, in Medicine, Surgery, and Collateral Sciences, July, 1895

Duguet mentions a case in which this condition followed repeated cauterisations of the throat with silver nitrate, and most of us are familiar with the appearance of a gentleman occasionally seen in the streets of Dublin in whom the con dition is said to have arisen from a similar cause.

Hutchinson b details two cases of general argyria, in which the history showed that the drug had only been applied externally - in the one case locally to syphilitic sores, and in the other case to the mouth and throat. The latter case Was a very remarkable one, inasmuch as the staining only appeared after the lapse of eight years.

Crocker alludes to a similar case, in which the blueness did not develop for many years after the topical applications had ceased to be made and Lombard d mentioned a case in which after a six years' pause in the administration of the drug, a staining of the skin followed its resumption for six months. Numerous other cases might be quoted where the condition followed the application of the drug to the surface of wounds and to its internal use for nervous and gastric affections.

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