This paper explores ways to unlock the potential for regional development and economic cooperation in the wider Central Asia region. It argues that understanding critical clusters of interrelated issues, and explicitly taking into account geopolitical and political economy considerations, are key in this regard. Regional countries and other stakeholders should focus on a few areas where there are real prospects for success in the short run, a combination of modest win-win initiatives and in some cases bold strokes that augment and change the distribution of benefits and hence make cooperation more likely to deliver progress.